Due to its central location in India, Nagpur Railway Station is an important railway junction and a transit for trains that connect the country lengthwise and breadthwise, especially trains connecting India's major metropolises (Mumbai, Delhi, Chennai,Kolkata,Hyderabad,Pune, Bangalore, Ahemedabad, Kanpur, Indore, Jaipur, Bhopal, Lucknow, Gwalior, Agra, Varanasi, Patna, Gaya and Jammu.

Nagpur is also a major junction for roadways as India's two major national highways (Kanyakumari-Varanasi (NH 7) and Hajira-Kolkata (NH-6)) pass through the city. One more highway number 69 connect Nagpur to Obaidullaganj near Bhopal. Nagpur is at the junction of two Asian Highways namely AH43 Agra to Matara, Sri Lanka and AH46 connecting Kharagpur, India to Dhule, India. Auto rickshaws operate in most parts of Nagpur and are the main form of hired transport within the city.

Nagpur's Air Traffic Control (ATC) is the busiest in India, with more than 300 international flights flying over the city every day in 2004. In October 2005, Nagpur's erstwhile Sonegaon Airport was declared an international airport and was renamed Dr. Babasaheb Ambedkar International Airport. Country's first ever international cargo hub, the Multi-modal International Cargo Hub and Airport at Nagpur (MIHAN) is planned on the outskirts of the city.